{"version":"1.0","type":"rich","provider_name":"Acast","provider_url":"https://acast.com","height":250,"width":700,"html":"<iframe src=\"https://embed.acast.com/$/1f6467be-211c-404e-ab67-4245d38358e2/69024a379b0ac9b4188d95f4?\" frameBorder=\"0\" width=\"700\" height=\"250\"></iframe>","title":"S6:E2 Magic Mushrooms and the Human Brain","thumbnail_width":200,"thumbnail_height":200,"thumbnail_url":"https://open-images.acast.com/shows/611ec3c406c05e78bff40dee/1761757921043-00a54f5e-0645-4d6f-a1e1-e39feafd88b4.jpeg?height=200","description":"<p>Psilocybin — the psychedelic compound in so-called “magic mushrooms” — has exploded into headlines and social media feeds. Some call it a miracle cure for depression, others dismiss it as hype. In this episode, I take a clear-eyed look at what the science really says.</p><p>I’ll start with Sarah’s story — a young scientist whose life was turned upside down by a cycling accident and who found hope again through a psilocybin clinical trial at Johns Hopkins. Her words: <em>“This trial changed my life.”</em></p><p>From there, I explore:</p><ul><li>The history of psilocybin, from ancient rituals to 1960s psychiatry to today’s “psychedelic renaissance.”</li><li>The <strong>online buzz</strong>, where psilocybin is hyped as everything from a creativity booster to a trauma cure.</li><li>The <strong>scientific evidence</strong>, from small pilot trials to the largest modern RCTs.</li><li>The <strong>neuroscience</strong>, showing how psilocybin may “reset” rigid brain networks, boost plasticity, and even dampen inflammation.</li><li>The <strong>risks</strong>, including panic, paranoia, and psychosis in vulnerable people.</li></ul><p>Finally, I’ll share my <strong>Tools in Three</strong> so you can separate the real promise from the hype.</p><p><br></p><p><br></p><p><strong>Featured Research</strong></p><ul><li>Carhart-Harris RL, et al. doi: <a href=\"https://doi.org/10.1016/S2215-0366(16)30065-7\" rel=\"noopener noreferrer\" target=\"_blank\">10.1016/S2215-0366(16)30065-</a></li><li>Carhart-Harris RL, et al.  doi: <a href=\"https://doi.org/10.1056/NEJMoa2032994\" rel=\"noopener noreferrer\" target=\"_blank\">10.1056/NEJMoa2032994</a></li><li>Davis AK, et al.  doi: <a href=\"https://doi.org/10.1001/jamapsychiatry.2020.3285\" rel=\"noopener noreferrer\" target=\"_blank\">10.1001/jamapsychiatry.2020.3285</a></li><li>Goodwin GM, et al. <em>S</em> <a href=\"https://doi.org/10.1056/NEJMoa2206443\" rel=\"noopener noreferrer\" target=\"_blank\">10.1056/NEJMoa2206443</a></li><li>Additional insights from <em>Nature Medicine</em> (Carhart-Harris, 2021) and <em>New Scientist</em> on brain plasticity and inflammation.</li></ul><p><br></p><p><em>Each episode explores what’s really going on inside your brain when you do the things you do — from the everyday to the extraordinary — and gives you three tools for your Super Brain kit. </em></p><p><br></p><p><strong><em>Sabina's books </em></strong></p><p><a href=\"https://www.orionbooks.co.uk/titles/sabina-brennan/the-neuroscience-of-manifesting/9781398716261/\" rel=\"noopener noreferrer\" target=\"_blank\"><strong><em>The Neuroscience of Manifesting </em></strong></a></p><p><a href=\"https://www.bloomsbury.com/uk/still-me-9781399421386/\" rel=\"noopener noreferrer\" target=\"_blank\"><strong><em>Still Me </em></strong></a></p><p><a href=\"https://www.orionbooks.co.uk/titles/sabina-brennan/100-days-to-a-younger-brain/9781409184973/\" rel=\"noopener noreferrer\" target=\"_blank\"><strong><em>100 Days to a Younger </em></strong></a></p><p><a href=\"https://www.orionbooks.co.uk/titles/sabina-brennan/beating-brain-fog/9781409197775/\" rel=\"noopener noreferrer\" target=\"_blank\"><strong><em>Brain Beating Brain Fog </em></strong></a></p><p><a href=\"https://www.orionbooks.co.uk/titles/sabina-brennan/brain-gym/9781399605052/\" rel=\"noopener noreferrer\" target=\"_blank\"><strong><em>Brain Gym in a Box</em></strong></a></p><p><br></p><p>Follow <a href=\"https://www.instagram.com/sabinabrennan/\" rel=\"noopener noreferrer\" target=\"_blank\">Sabina Brennan</a> on Instagram</p>","author_name":"Sabina Brennan"}